Clinic characteristics and laser therapy on Nevus of Ota and Acquired bilateral nevus of Ota-like maculae

Keywords:medical fiber, laser fiber,  Time:28-08-2015

Nevus of Ota, synonymously termed nevus fuscoceruleus ophthalmomaxillaris,oculodermal melanosis, is a dermal hyperpigmentation along the first or second branches of the trigeminal nerve. Acquired bilateral nevus of Ota-like maculae（ABNOM） or nevus fuscoceruleus zygomaticus, Hori’ nevus, is bilateral, brown and blue-gray pigmentation over the face. The sites involved include the forehead, malar area, temples, eyelids, root of the nose and ala nasi. Owing to lesions located on the face, Nevus of Ota and ABNOM often frustrates the patients. In China, the incidence of Nevus of Ota is determined to be 0.1-0.2%, and the incidence of ABNOM is approx to 2.5%. The quantity of patients both Nevus of Ota and ABNOM would be more than 3 million.

Key word：Nevus of Ota、Medical Fiber、clinical analysis、Quality-switched laser、treatment

Study design
In order to conclude the clinic characteristics and therapy of Nevus of Ota and ABNOM,this research, composed with two parts, was carried out. During January, 2006～January,2011, a total of 434 nevus of Ota patients and 328 ABNOM patients, which were confirmed diagnosis of by plastic surgery center of Southwest Hospital affiliated to the Third military medical university, were retrospective analyzed, involved sex, age, age of onset, onset time,color, distribution and size of skin lesions, and so on, and compared the clinical characteristics between Nevus of Ota and ABNOM. Subsequently, search the studies about the nevus of Ota and ABNOM Q-switched laser treatment in PubMed. To approach the preferred therapy, the clinical data including laser parameter, therapeutic effect, complications were systemicanalyzed.

Results
Search the studies about the Nevus of Ota and ABNOM Quality-switched laser treatment before December 2011 at PubMed, and 30 studies are included. After the systemic analysis,the results to approach the preferred therapy are illustrated as followed. Firstly, Nevus of Ota is much more sensitive to Quality-switched laser than ABNOM. Secondly, different race appear different effects of Quality-switched laser irradiation on the lesions. Thirdly, the laser parameters contribute to effect and complication. The treatment session, fluence, pulse duration are considered as key factors, and teatment interval, teatment end point, spot size and so on appear insignificantly. Fourthly, Quality-switched ruby laser (QSRL) is better than Quality-switched alexandrite laser (QSAL) in treating Nevus of Ota and ABNOM.Additionally, Quality-switched neodymium:yttrium-aluminum-garnet laser (QSNYL) would be more satisfactory, despite deficient evaluation about the effect of QSNYL.

Conclusion
1. Recently, clinic characteristics of Nevus of Ota and ABNOM have some changes.Considering with some changes of relevant diseases in the same area of sampling, EDCs would be the key point, which include these changes. Polycyclic aromatic hydrocarbons (PAHs) is the capital member of EDCs, and PAHs is able to modulate melanogenesis by the androgen receptor (AR) and aryl hydrocarbon receptor (AHR) signaling pathways. This study focuses on the changes of clinic characteristics, in posed to approach the pathogenesis.
2. This study analyzes the factors, which could effect the therapy results and suggest atrea tment for information to conduct the clinic treatment.